Strongbridge CareConnection Patient Support

Strongbridge CareConnection - Patient Support Program

Strongbridge CareConnection makes sure your patients are getting the support they need

Strongbridge is committed to providing a wide range of services and support for your patients living with Primary Periodic Paralysis and their family members. Call 844-KEVEYIS (538‑3947) for more information on any of the patient support services listed below.

One-on-one support

  • A dedicated case manager is assigned to every patient
  • Patient access managers are available to work with healthcare providers and patients to overcome common barriers to therapy
  • Patients receive routine calls from a licensed pharmacist, which focus on their progress and treatment goals

Genetic testing

  • Uncovering Periodic Paralysis is a no-cost gene panel testing program for patients who may have PPP as well as their eligible first-degree family members
  • The Periodic Paralysis Panel includes analysis for both hyperkalemic and hypokalemic periodic paralysis, testing for the three most common associated genes: SCN4A, CACNA1S, and KCNJ2
  • Visit www.UncoveringPeriodicParalysis.com to order a genetic test or request a specimen collection kit

Access assistance

  • Access and support for patients with and without insurance
  • Information on a $0 co-pay program and other financial assistance
  • Convenient, free specialty pharmacy services, including 24/7 support and home delivery of prescription

Patient education

  • Patient-friendly information on Primary Periodic Paralysis and its management and treatment

Community connection

  • Links to online patient communities and advocacy organizations
To learn more about genetic testing for Primary Periodic Paralysis, download this helpful resource.

*Eligible patients pay as little as $0 with a maximum annual savings of $10,000. The authorized specialty pharmacy will activate the copay card for eligible patients and apply for each prescription until the annual maximum has been reached. This card is not valid for prescriptions that may be reimbursed under a federal or state healthcare program, including Medicare, Medicaid, or any other similar federal or state healthcare program, including any state pharmacy assistance program. For additional questions about the co-pay program, including eligibility, call Strongbridge CareConnection at 844-KEVEYIS (538‑3947)

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Indication

KEVEYIS is indicated for the treatment of primary hyperkalemic periodic paralysis, primary hypokalemic periodic paralysis, and related variants.

Important Safety Information

CONTRAINDICATIONS

  • Hypersensitivity to dichlorphenamide or other sulfonamides
  • Concomitant use of KEVEYIS and high-dose aspirin
  • Severe pulmonary disease, limiting compensation to metabolic acidosis caused by KEVEYIS
  • Hepatic insufficiency: KEVEYIS may aggravate hepatic encephalopathy

WARNINGS AND PRECAUTIONS

Hypersensitivity/Anaphylaxis/Idiosyncratic Reactions

  • Fatalities associated with the administration of sulfonamides have occurred due to adverse reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia and other blood dyscrasias
  • Pulmonary involvement can occur in isolation or as part of a systemic reaction
  • Discontinue KEVEYIS at the first appearance of skin rash or any sign of immune-mediated or idiosyncratic adverse reaction

Concomitant Use of Aspirin

  • Anorexia, tachypnea, lethargy, and coma have been reported with concomitant use of dichlorphenamide and high-dose aspirin
  • The concomitant use of KEVEYIS and high-dose aspirin is contraindicated
  • Use with caution in patients receiving low-dose aspirin

Hypokalemia

  • KEVEYIS increases potassium excretion and can cause hypokalemia
  • The risk of hypokalemia is greater when KEVEYIS is used in patients with conditions associated with hypokalemia (eg, adrenocortical insufficiency, hyperchloremic metabolic acidosis, or respiratory acidosis), and in patients receiving other drugs that may cause hypokalemia (eg, loop diuretics, thiazide diuretics, laxatives, antifungals, penicillin, and theophylline)
  • Baseline and periodic measurements of serum potassium are recommended
  • If hypokalemia develops or persists, consider reducing the dose or discontinuing KEVEYIS

Metabolic Acidosis

  • KEVEYIS can cause hyperchloremic non–anion gap metabolic acidosis
  • Concomitant use of KEVEYIS with other drugs that cause metabolic acidosis may increase the severity of metabolic acidosis
  • Baseline and periodic measurements of serum bicarbonate are recommended
  • If metabolic acidosis develops or persists, consider reducing the dose or discontinuing KEVEYIS

Falls

  • KEVEYIS increases the risk of falls; risk is greater in the elderly and with higher doses
  • Consider dose reduction or discontinuation of KEVEYIS in patients who experience falls while treated with KEVEYIS

PREGNANCY AND LACTATION

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known in humans whether dichlorphenamide is excreted in human milk; exercise caution when administered to a nursing woman.

ADVERSE REACTIONS

The most common adverse reactions seen in clinical trials (incidence ≥ 10% and greater than placebo) include paresthesias, cognitive disorder, dysgeusia, and confusional state.

Please see Full Prescribing Information.