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KEVEYIS can help you gain greater control of Primary Periodic Paralysis

What is KEVEYIS?

KEVEYIS (dichlorphenamide), pronounced “keh-VAY-iss,” is the only prescription medication for hyperkalemic, hypokalemic, and related variants of Primary Periodic Paralysis.

KEVEYIS has been proven effective in treating Primary Periodic Paralysis. It can help you gain greater control over the disease by decreasing the number, severity, and frequency of attacks.1,2*

*Individual results may vary.

Patient Ambassador

“Now I feel like I’ve been able to gain greater control over my condition—I don’t have to worry about coming down with bouts of weakness or paralysis as often as I used to.”

How effective is KEVEYIS?

KEVEYIS has been studied in 2 separate clinical studies and was proven to be an effective treatment for Primary Periodic Paralysis.1,2

When compared with placebo (an inactive pill) in one study…
In 2 separate clinical studies, KEVEYIS has been proven to be an effective treatment for Primary Periodic Paralysis.
When compared with placebo in a second study…
In 2 separate clinical studies, KEVEYIS has been proven to be an effective treatment for Primary Periodic Paralysis.

Patient Ambassador

“It wasn’t long before I noticed that the number of my attacks had decreased, and overall we have been pleased with my results.”

Patient Ambassador

“On KEVEYIS, a lot of my usual hyperkalemic periodic paralysis symptoms have gone away, like waking up in the morning and not being able to move. I have had fewer episodes.”

What are the most common side effects with KEVEYIS?

In the key clinical study, some of the most common side effects of KEVEYIS were1:

Side effects of Keveyis may include tingling sensations, foggy or confused feelings, or changes in taste and should be discussed with your doctor.

Based on how you respond to treatment, your KEVEYIS dose may be adjusted. If you experience side effects that get worse while taking KEVEYIS, your doctor may reduce your daily dose to better manage these side effects. And, if you begin to experience any new side effects, be sure to talk to your doctor right away.1

Patient Ambassador

“After starting KEVEYIS, I did have some tingling in my fingers and lips. My vision was also a little blurry, but these side effects subsided in time.”

Patient Ambassador

“After starting KEVEYIS, I felt dizzy, but I talked with my doctor about it, and we figured out a way to manage it.”

Patient Ambassador

“I do sometimes feel tingling in my face with KEVEYIS. But that has not happened often, and I’ve worked with my doctor on managing that side effect.”

How do I take KEVEYIS?

KEVEYIS is a tablet that you take by mouth once or twice daily, depending on what your doctor has prescribed.1

There is a recommended starting dose. However, the amount of KEVEYIS you will take may change based on your specific needs and whether or not you experience any side effects. Your doctor may decide to increase or decrease your initial dose, depending on your response. You should be sure to take KEVEYIS exactly as your doctor has recommended for you.1

Strongbridge CareConnection is designed to provide a wide range of services and support for patients like you and your family members. Learn more.

Patient Ambassador

“I learned that the treatment dose could be increased or decreased based on my clinical response. So, I worked with my doctor to individualize my dosing regimen.”


Indication and Important Safety Information

What is KEVEYIS?

KEVEYIS (pronounced keh-VAY-iss) (dichlorphenamide) is a prescription drug used to treat primary hyperkalemic periodic paralysis, primary hypokalemic periodic paralysis, and other similar diseases.

What should you tell your healthcare provider before taking KEVEYIS?

Tell your doctor if you are allergic to dichlorphenamide or other sulfa drugs; if you take high doses of aspirin, or if you have lung or liver disease; if you are pregnant, plan to become pregnant, or are breastfeeding or plan to breastfeed.

What should you know about KEVEYIS?

  • Severe allergic and other reactions have happened with sulfonamides (drugs such as KEVEYIS) and have sometimes been fatal. Stop taking KEVEYIS at the first sign of skin rash, swelling, difficulty breathing, or any other unexpected side effect or reaction, and call 911 right away.
  • Tell your healthcare provider if you take aspirin or if another healthcare provider instructs you to begin taking aspirin. High doses of aspirin should not be taken with KEVEYIS.
  • KEVEYIS can cause your body to lose potassium, which can lead to heart problems. Your healthcare provider will measure the potassium levels in your blood before you start treatment and at certain times during treatment.
  • Tell your healthcare provider about all other prescription and over-the-counter medicines you take, including supplements, as some medicines can interact with KEVEYIS.
  • While taking KEVEYIS, your body may produce too much acid or may not be able to remove acid from the body. Your healthcare provider may run tests on a regular basis to check for signs of acid buildup.
  • KEVEYIS may increase your risk of falling. Tell your healthcare provider right away if you experience a fall while taking KEVEYIS.
  • The risks of falls and acid buildup are greater in elderly patients.
  • It is not known whether KEVEYIS is safe or effective for people younger than 18 years of age.

What are the most common side effects with KEVEYIS?

The most common side effects are a feeling of numbness, tingling or burning (“pins and needles”) in the toes, feet, hands or fingers; trouble with memory or thinking; feeling confused; and unpleasant taste in the mouth.

These are not all of the possible side effects of KEVEYIS. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.


  1. KEVEYIS [package insert]. Feasterville-Trevose, PA: Strongbridge Biopharma; 2019.
  2. Sansone VA, Burge J, McDermott MP, et al; for the Muscle Study Group. Randomized, placebo-controlled trials of dichlorphenamide in periodic paralysis. Neurology. 2016;86:1408-1416.